Main Difference
The main difference between Regulation and Guideline is that the Regulation is a general term for rules, including delegated legislation and self-regulation and Guideline is a statement by which to determine a course of action
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Regulation
Regulation is an abstract concept of management of complex systems according to a set of rules and trends. In systems theory, these types of rules exist in various fields of biology and society, but the term has slightly different meanings according to context. For example:
in biology, gene regulation and metabolic regulation allow living organisms to adapt to their environment and maintain homeostasis;
in government, typically regulation means stipulations of the delegated legislation which is drafted by subject-matter experts to enforce primary legislation;
in business, industry self-regulation occurs through self-regulatory organizations and trade associations which allow industries to set and enforce rules with less government involvement; and,
in psychology, self-regulation theory is the study of how individuals regulate their thoughts and behaviors to reach goals.
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Guideline
A guideline is a statement by which to determine a course of action. A guideline aims to streamline particular processes according to a set routine or sound practice. Guidelines may be issued by and used by any organization (governmental or private) to make the actions of its employees or divisions more predictable, and presumably of higher quality. A guideline is similar to a rule.
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Regulation (noun)
The act of regulating or the condition of being regulated.
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Regulation (noun)
A law or administrative rule, issued by an organization, used to guide or prescribe the conduct of members of that organization.
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Regulation (noun)
A form of legislative act which is self-effecting, and requires no further intervention by the Member States to become law.
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Regulation (noun)
Mechanism controlling DNA transcription.
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Regulation (noun)
Physiological process which consists in maintaining homoeostasis.
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Regulation (adjective)
In conformity with applicable rules and regulations.
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Guideline (noun)
A non-specific rule or principle that provides direction to action or behaviour.
“He considered the Ten Commandments more a guideline than a requirement.”
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Guideline (noun)
A plan or explanation to guide one in setting standards or determining a course of action.
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Guideline (noun)
A light line, used in lettering, to help align the text.
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Regulation (noun)
a rule or directive made and maintained by an authority
“planning regulations”
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Regulation (noun)
in accordance with regulations; of the correct type
“regulation army footwear”
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Regulation (noun)
of a familiar or predictable type; formulaic
“a regulation Western parody”
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Regulation (noun)
the action or process of regulating or being regulated
“the regulation of financial markets”