Aging vs. Senescence

By Jaxson

Main Difference

The main difference between Aging and Senescence is that the Aging is a developmental process that is a deterioration and loss of function over time and Senescence is a gradual deterioration of function characteristic of most complex lifeforms

  • Aging

    Ageing or aging (see spelling differences) is the process of becoming older. The term refers especially to human beings, many animals, and fungi, whereas for example bacteria, perennial plants and some simple animals are potentially immortal. In the broader sense, ageing can refer to single cells within an organism which have ceased dividing (cellular senescence) or to the population of a species (population ageing).

    In humans, ageing represents the accumulation of changes in a human being over time, encompassing physical, psychological, and social changes. Reaction time, for example, may slow with age, while knowledge of world events and wisdom may expand. Ageing is among the greatest known risk factors for most human diseases: of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes.

    The causes of ageing are uncertain; current theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA oxidation) may cause biological systems to fail, or to the programmed ageing concept, whereby internal processes (such as DNA methylation) may cause ageing. Programmed ageing should not be confused with programmed cell death (apoptosis).

    The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats has motivated research into delaying and preventing ageing.

  • Senescence

    Senescence () or biological aging is the gradual deterioration of functional characteristics. The word senescence can refer either to cellular senescence or to senescence of the whole organism. Organismal senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the latter part of an organism’s life cycle.

    Senescence is the inevitable fate of all multicellular organisms with germ-soma separation, but it can be delayed. The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats, and the existence of species having negligible senescence and potentially immortal organisms such as Hydra, have motivated research into delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases.

    Environmental factors may affect aging, for example, overexposure to ultraviolet radiation accelerates skin aging. Different parts of the body may age at different rates. Two organisms of the same species can also age at different rates, making biological aging and chronological aging distinct concepts.

  • Aging (verb)

    present participle of age

  • Aging (noun)

    The process of becoming older or more mature.

  • Aging (noun)

    The deliberate process of making something (such as an antique) appear older than it is.

  • Aging (noun)

    Becoming senescent; accumulating damage to macromolecules, cells, tissues and organs with the passage of time.

  • Aging (adjective)

    Becoming elderly.

    “The aging artist could no longer steadily hold the brush.”

  • Senescence (noun)

    The state or process of ageing, especially in humans; old age.

  • Senescence (noun)

    Ceasing to divide by mitosis because of shortening of telomeres or excessive DNA damage.

  • Senescence (noun)

    Old age; accumulated damage to macromolecules, cells, tissues and organs with the passage of time.

  • Senescence (noun)

    Fruit senescence, leading to ripening of fruit.

  • Senescence (noun)

    Condition when the cell ceases to divide.


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